Heptelidic acid - CAS 57710-57-3

Heptelidic acid (Koningic acid) is a sesquiterpenoid lactone antibiotic derived from the probiotic fungus Aspergillus oryzae, a selective GAPDH inhibitor. It downregulates caspase to inhibit etoposide-induced apoptosis. Heptelidic acid inhibits tau fibrillation in a concentration-dependent manner and exerts antitumor effects on extra-intestinal melanoma by controlling glyceraldehyde-3-phosphate dehydrogenase activity.

Antibiotic, Apoptosis, Caspase

Proteases/Proteasome, Microbiology/Virology, Apoptosis

57650

C15H20O5

280.32

O=C1[C@@]2([C@]3(CO3)CC[C@H](C(C)C)[C@]2(C=C(C(O)=O)CO1)[H])[H]

-20°C

Ice Packs

Natural Product