HG-7-85-01-NH2 - CAS 1258391-29-5

HG-7-85-01-NH2, as the ligand for SNIPER (ABL) -033, effectively induces the reduction of BCR-ABL protein. This is achieved through SNIPER (ABL) -033, which connects HG-7-85-01 (an ABL inhibitor) to an LCL161 derivative (an IAP ligand) using a linker, demonstrating a DC50 value of 0.3 μM [1].

Ligands for Target Protein for PROTAC, Others, PROTACs, SNIPERs, Bcr-Abl

Cytoskeletal Signaling, Angiogenesis, Others, Tyrosine Kinase/Adaptors, PROTAC

1258391-29-5

C27H27F3N6OS

540.6

C(C1=C(C(F)(F)F)C=C(NC(=O)C2=CC(=CC=C2)C=3N=C4C(=CC3)N=C(N)S4)C=C1)N5CCN(CC)CC5

-20°C

Ice Packs

PROTAC