HGC652 - CAS 3055558-98-7

HGC652 is a molecular glue that targets the E3 ubiquitin ligase TRIM21, facilitating the formation of a ternary complex between TRIM21 and NUP98, which induces the degradation of NUP155 and nuclear pore complex proteins, ultimately leading to cell death. HGC652 inhibits the proliferation of various cancer cells, with its antiproliferative activity depending on the expression level of TRIM21.

E1/E2/E3 Enzyme, Molecular Glues

Ubiquitination, PROTAC

3055453

C23H28FNO3S2

449.602

O=C(C=1C=CC(=CC1S(=O)(=O)C)C2=CC=C(F)C=C2SC)N(C)CC3CCCCC3

-20°C

Ice Packs

PROTAC