HI042 - CAS 898168-15-5

HI042 is an FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing an IC50 value of 0.62 μM for MOLM-13 cells, 0.33 μM for MV4-11 cells, and 0.89 μM for OCI-AML3 cells. It selectively reduces the survival rate of FLT3-internal tandem duplication (FLT3-ITD) positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes colony-forming ability. HI042 is applicable for acute myeloid leukemia (AML) research.

Apoptosis, FLT

Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors

898148

C14H11N3O3S

301.32

O=C(C=CC=1C=CC=CC1)NN=CC=2SC(=CC2)N(=O)=O

-20°C

Ice Packs

Small Compound