Hinokiflavone - CAS 19202-36-9

Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO protease inhibitor by impeding the activity of sentrin-specific protease 1 (SENP1) . Hinokiflavone also demonstrates significant cytotoxicity, including the inhibition of MMP-9.

Apoptosis, Bcl-2 Family, Protease, E1/E2/E3 Enzyme, MMP

Ubiquitination, Apoptosis, Proteases/Proteasome

19157

0.9867

C30H18O10

538.46

Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1

-20°C

Ice Packs

Natural Product