HIV-1 inhibitor-16 - CAS 2719675-72-4

HIV-1 inhibitor-16 (compound 7a) is a potent HIV-1 inhibitor with an EC50 of 1.3 nM against wild-type HIV-1, and exhibits inhibitory activity against HIV-1 K103N, E138K, Y181C, and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. It demonstrates good solubility, hepatic microsomal stability, and lacks significant CYP enzyme inhibitory activity or acute toxicity.

Others, HIV Protease

Microbiology/Virology, Others, Proteases/Proteasome

2719599

C23H16F2N6

414.41

FC=1C=C(C=C(F)C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2C)C=4C=CN=CC4

-20°C

Ice Packs

Small Compound