HIV-1 inhibitor-24 - CAS 2475658-75-2

HIV-1 inhibitor-24 (compound S-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 9.5 nM. It exhibits a high antiviral effect on wild-type HIV-1, showing an EC50 value of 1.6 nM and low cytotoxicity (CC50 on MT-4 cells) . HIV-1 inhibitor-24 was well tolerated in mice at a dose of 2 g/kg and demonstrated a significant cardiovascular safety profile.

Others, HIV Protease

Proteases/Proteasome, Others, Microbiology/Virology

2475581

C26H19N5O2

433.46

[C@H](O)(C1=C(OC)C=C(C=C1)C2=CC=C(C#N)C=C2)C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3

-20°C

Ice Packs

Small Compound