HJC-0123 - CAS 1430420-02-2

Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER) -negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.

Apoptosis, STAT, Others, Interleukin, TGF-beta/Smad

JAK/STAT signaling, Apoptosis, Immunology/Inflammation, Others, Stem Cells

1430420-02-2

C24H16N2O3S

412.46

C(NC=1C=C2C(=CC1)C=CS2(=O)=O)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4

-20°C

Ice Packs

Small Compound