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Molfinity

HKI-357 - CAS 848133-17-5

HKI-357 - CAS 848133-17-5

MF-0019333-01

$51.86 USD
$51.86 USD
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Product Details

  • Bioactivity

    HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.

  • Target

    EGFR

  • Related Pathways

    JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors

  • CAS Number

    848111

  • Purity

    0.9991

  • Molecular Formula

    C31H29ClFN5O3

  • Molecular Weight

    574.05

  • SMILES

    CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound