Molfinity

HKI-357 dimaleate - CAS 915942-25-5

SKU:MF-0143233-01

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Product Details

Bioactivity
HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
Target
Others, EGFR
Related Pathways
Others, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
CAS Number
915912
Molecular Formula
C39H37ClFN5O11
Molecular Weight
806.2
SMILES
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound