HL001 - CAS 1186371-31-2

HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1) . It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.

LPL Receptor, Reactive Oxygen Species, Apoptosis, MDM-2/p53

NF-κB, Apoptosis, GPCR/G Protein, Metabolism, Immunology/Inflammation

1186338

C21H16N2O4

360.363

O=C(NC(=O)C=1C(O)=CC=CC1O)NC2C=3C=CC=CC3C=4C=CC=CC42

-20°C

Ice Packs

Small Compound