HL23 - CAS 1448355-15-4

HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC) . It promotes acetylation at the TXNIP promoter and increases TXNIP expression, modulating potassium channel activity and inducing TXNIP-dependent potassium deficiency. Additionally, HL23 impedes HCC progression and spread, demonstrating greater potency when combined with Sorafenib than the Sorafenib and Vorinostat duo [1].

Others, HDAC

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

1448336

C44H44N2O7

712.83

O(C(=O)C1=CC=CC=C1)C2=C3C=4[C@](CC=5C=C(C(OC)=CC5)OC=6C=CC(C[C@]7(C8=CC(O3)=C(OC)C=C8CCN7C)[H])=CC6)(N(C)CCC4C=C2OC)[H]

-20°C

Ice Packs

Small Compound