HMCH-1R antagonist 1 - CAS 353487-64-6

HMCH-1R Antagonist 1 (Compound 30) serves as an effective and selective antagonist for the human melanin-concentrating hormone receptor 1 (hMCHR1), exhibiting a K_B value of 3.6 nM. It possesses the ability to bind to hMCHR1 and hMCHR2, with IC_50 values of 65 nM and 49 nM, respectively. This compound is applicable in metabolic research [1].

GPCR, Melanin-concentrating Hormone Receptor (MCHR)

Endocrinology/Hormones, GPCR/G Protein

353417

C49H82N16O11S3

1167.47

CSCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CCCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCCCNC1=O)C(C)C)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O

-20°C

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