HOIPIN-8 sodium - CAS 2519537-70-1

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.

IκB/IKK, E1/E2/E3 Enzyme

Ubiquitination, NF-κB

2519537-70-1

0.9734

C23H15F2N4NaO3

456.38

O=C(C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+]

-20°C

Ice Packs

Small Compound