Homer - CAS 2737222-94-3

Homer is a probe designed to target WD repeat domain 5 (WDR5) . In MV4-11 cells, Homer induces the degradation of WDR5 with a half-maximal degradation concentration (DC50) of 53 nM. At a concentration of 1 μM, Homer decreases the protein levels of WDR5 in MV4-11 cells without affecting the mRNA levels that encode WDR5.

DNA/RNA Synthesis, Others, PROTACs

PROTAC, Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2737125

C52H60F3N9O7S

1012.15

N(C(=O)C=1C(C(F)(F)F)=CC(=O)NC1)C2=C(C=CC(=C2)C3=CC=C(C(NCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)C=C3)N7CCN(C)CC7

-20°C

Ice Packs

Dye-Reagents