Homogentisic acid - CAS 451-13-8

1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidants. 2. Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. 3. A derivative of homogentisic acid which inhibits Pfnek-1 with an IC (5) around 1.8 muM, this product is moderately active in vitro against a FcB1 P. falciparum strain (IC (5) = 12 muM) .

Endogenous Metabolite, Antioxidant

Metabolism, Oxidation-Reduction

430

0.9988

C8H8O4

168.15

OC(=O)Cc1cc(O)ccc1O

-20°C

Ice Packs

Natural Product