HPK1-IN-2 - CAS 2056122-11-1

HPK1-IN-2 (Thieno[2,3-b]pyridin-6 (7H) -one, 4-amino-5-[6- (4-methyl-1-piperazinyl) -1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ) . It also inhibits Lck (0.05 μΜ<IC50<0.5 μΜ) and Flt3 (IC50<0.05 μΜ) kinase activities with antitumor activity.

FLT, Src

Angiogenesis, Tyrosine Kinase/Adaptors

2056110

0.9962

C19H20N6OS

380.47

NC1=C(C=2NC=3C(N2)=CC=C(C3)N4CCN(C)CC4)C(=O)NC5=C1C=CS5

-20°C

Ice Packs

Small Compound