HPK1-IN-2 dihydrochloride - CAS 2375595-72-3

HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 μM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 μM, and Flt3 kinase activity, with an IC 50 of less than 0.05 μM [1].

Others, MAPK, FLT, Src

MAPK, Others, Angiogenesis, Tyrosine Kinase/Adaptors

2375595-72-3

C19H22Cl2N6OS

453.39

NC1=C(C=2NC=3C(N2)=CC=C(C3)N4CCN(C)CC4)C(=O)NC5=C1C=CS5.Cl

-20°C

Ice Packs

Small Compound