HPK1-IN-55 - CAS 3048537-58-9

HPK1-IN-55 (compound 19) is a selective and orally active inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of less than 0.51 nM. It exhibits exceptional kinase selectivity, being over 637 times more selective for HPK1 compared to GCK kinase and over 1022 times compared to LCK. HPK1-IN-55 possesses anti-cancer properties.

MAPK

MAPK

3048470

C30H34N8O3

554.643

O=C(N)C1=NC(=C(OC)C=C1NC=2N=C3C(=CC2)C4(N(C)C3)CCN(CC4)C5COC5)C6=CC=CC7=C6N=CN7C

-20°C

Ice Packs

Small Compound