HPK1-IN-56 - CAS 2901054-39-3

HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.

Interleukin, MAPK

Immunology/Inflammation, MAPK

2901012

C24H26N8O

442.516

N1=NC=2C(N=C1NC=3C=C4C(=CC3OC)CCN(C)C4)=CC(=CC2N)C=5C=NC=C(N)C5C

-20°C

Ice Packs

Small Compound