HPK1-IN-61 - CAS 875638-86-1

HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.

MAPK, Src, Bcr-Abl

Cytoskeletal Signaling, MAPK, Angiogenesis, Tyrosine Kinase/Adaptors

875551

C23H22N4O2

386.45

O=C(C=1C=C(C=CC1N)C2=CN=C3NC=C(C=4C=CC=CC4OC)C3=C2)N(C)C

-20°C

Ice Packs

Small Compound