HPO-DAEE - CAS 1895934-61-8

HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) performs multiple roles in cellular processes, primarily enhancing nuclear accumulation of Nrf2 and activating the antioxidant response element (ARE) . It upregulates antioxidant genes such as HO-1 through Nrf2-ARE signaling and initiates the generation of reactive oxygen species. Additionally, HPO-DAEE inhibits histone deacetylase, promoting the expression of extracellular superoxide dismutase via histone acetylation. It offers protection against 6-hydroxydopamine-induced cell death by activating the Nrf2-ARE and eIF2α-ATF4 pathways [1].

ROS, Reactive Oxygen Species, HDAC

DNA Damage/DNA Repair, Metabolism, Immunology/Inflammation, Chromatin/Epigenetic, NF-κB

1895934-61-8

C12H22O4

230.3

C(C=CC(OCC)=O)(CCCCCC)OO

-20°C

Ice Packs

Small Compound