HS56 - CAS 922050-57-5

HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor, displaying K_i values of 0.26 μM for DAPK3, 0.208 μM for Pim-3, 2.94 μM for Pim-1, and >100 μM for Pim-2. This compound effectively inhibits LC20 phosphorylation and smooth muscle contraction, and reduces blood pressure in spontaneously hypertensive mice, making it a valuable tool for hypertension research [HS-56].

Pim, Others, DAPK

JAK/STAT signaling, Others, Chromatin/Epigenetic, Apoptosis

921988

C13H8ClN5OS

317.75

O=C1C2=C(N(N=C2)C3=CC(Cl)=CC=C3)NC(SCC#N)=N1

-20°C

Ice Packs

Small Compound