HSD17B13-IN-104 - CAS 3075100-76-1

HSD17B13-IN-104 (Compound 32) is an orally active and potent inhibitor of HSD17B13 with high selectivity (IC50=2.5 nM) . It modulates liver lipid metabolism by inhibiting the SREBP-1c/FAS pathway and blocks the enzymatic activity of HSD17B13 to alleviate hepatic lipid accumulation. HSD17B13-IN-104 shows potential for research in metabolic dysfunction-associated fatty liver disease.

Dehydrogenase

Metabolism

3075023

C21H18ClF3N2O2S

454.89

O=C(C=1SC(=NC1C)C=2C=C(F)C(F)=C(O)C2F)N(CC3=CC=C(Cl)C=C3)C(C)C

-20°C

Ice Packs

Small Compound