HSD17B13-IN-17 - CAS 2758802-10-5

HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) . It demonstrates inhibitory efficacy with IC50 values of <0.1 μM for estradiol and <1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].

Dehydrogenase

Metabolism

2758802-10-5

C20H16ClFN2O3S

418.87

C(NCCC1=C(F)C=CC=C1)(=O)C2=C(NC(=O)C3=CC(Cl)=C(O)C=C3)C=CS2

-20°C

Ice Packs

Small Compound