HSD17B13-IN-21 - CAS 2758802-18-3

HSD17B13-IN-21 (compound 17) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 of < 0.1 μM for estradiol and < 1 μM for Leukotriene B3 as substrates. This compound plays a crucial role in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].

Dehydrogenase

Metabolism

2758802-18-3

C21H18Cl2N2O4S

465.35

C(NCCC1=C(OC)C=CC=C1)(=O)C2=C(NC(=O)C3=CC(Cl)=C(O)C=C3)C=C(Cl)S2

-20°C

Ice Packs

Small Compound