HSD17B13-IN-28 - CAS 2770246-42-7

HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].

Dehydrogenase

Metabolism

2770246-42-7

C23H16Cl2FN3O3

472.3

N(C(=O)C1=CC(Cl)=C(O)C(Cl)=C1)C2=C3C(N=CN([C@H](C)C4=CC(F)=CC=C4)C3=O)=CC=C2

-20°C

Ice Packs

Small Compound