HSD17B13-IN-31 - CAS 2758802-33-2

HSD17B13-IN-31 (compound 32) serves as a highly effective inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), demonstrating an IC50 of less than 0.1 μM and less than 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is critical in managing nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].

Dehydrogenase

Metabolism

2758802-33-2

C21H18Cl2N2O4S

465.35

N(C(=O)C1=CC(Cl)=C(O)C(Cl)=C1)C2=C(C(NCCC3=C(OC)C=CC=C3)=O)SC=C2

-20°C

Ice Packs

Small Compound