HSD17B13-IN-40 - CAS 2770246-06-3

HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].

Dehydrogenase

Metabolism

2770246-06-3

C23H14Cl2F3N3O3

508.28

N(C(=O)C1=CC(Cl)=C(O)C(Cl)=C1)C2=C3C(N=CN(CC4=CC=C(C(F)(F)F)C=C4)C3=O)=CC=C2

-20°C

Ice Packs

Small Compound