HSMG-1 inhibitor 11j - CAS 1402452-15-6

HSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM) . hSMG-1 inhibitor 11j can be used for the research of cancer.

PI3K, mTOR, GSK-3, CDK

PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Stem Cells

1402431

0.9965

C27H28ClN7O3S

566.07

CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl

-20°C

Ice Packs

Small Compound