HSN748 - CAS 2409925-53-5

HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.

MNK, c-RET, FLT, PDGFR, Bcr-Abl

MAPK, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis

2409867

C27H24F3N7O

519.521

O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=NC=C(C#CC4=CN=C5C=CC=NN45)C3

-20°C

Ice Packs

Small Compound