Hsp90-IN-38 - CAS 3065556-04-6

Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein) . It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.

HSP, ATPase

Cytoskeletal Signaling, Membrane transporter/Ion channel, Metabolism

3065556-04-6

C28H35N3O5

493.595

C(=O)(N1[C@@H](C(NCCCN2CCOCC2)=O)C[C@@H](C1)C3=CC=CC=C3)C4=CC(=C(O)C=C4O)C5CC5

-20°C

Ice Packs

Small Compound