HSV-1/HSV-2-IN-3 - CAS 3016396-78-1

HSV-1/HSV-2-IN-3 inhibits the helicase-primase complex of herpes simplex virus (HSV), interfering with the crucial processes of DNA unwinding and primer synthesis necessary for viral genome replication. In gD immunofluorescence assays containing 2% FBS, its EC50 against HSV-2 is 7.0 nM, while in assays with 10% human serum, the EC50 is 57.5 nM. Within qPCR replication analysis, the compound demonstrates an EC50 of 1.1 nM. Additionally, HSV-1/HSV-2-IN-3 exhibits strong selectivity against off-target interactions with human carbonic anhydrase (IC50 for hCA II ≈ 2.9 μM, and > 35 μM for hCA I) . This compound is applicable in anti-HSV research.

HSV

Microbiology/Virology

3016317

C24H22FN3O3S

451.51

C(=O)(N1C=2C(C[C@H]1C)=CC(F)=C(S(N)(=O)=O)C2)[C@H]3CC=4C(C3)=CC=C(C4)C5=CC=CC=N5

-20°C

Ice Packs

Small Compound