HTH-01-091 - CAS 2000209-42-5

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.

MTOR, DYRK, Serine/threonin kinase, GSK-3, Pim, MELK, CDK, RIP kinase

Cell Cycle/Checkpoint, JAK/STAT signaling, Chromatin/Epigenetic, Apoptosis, Metabolism, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, NF-κB, Stem Cells

2000162

0.9882

C26H28Cl2N4O2

499.43

O=C1N(C2=C3C(=NC=C2CN1)C=CC(=C3)C4=CC(Cl)=C(O)C(Cl)=C4)[C@@H]5CC[C@@H](CN(C)C)CC5

-20°C

Ice Packs

Small Compound