HTS05585 - CAS 696643-14-8

HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.

MIF

Immunology/Inflammation

696621

C18H15N3O

289.33

N=1OC(=CC1C=2C=CC=CC2)C=3N=C4C=C(C=CN4C3)CC

-20°C

Ice Packs

Small Compound