HuR degrader 2 - CAS 3040301-46-7

HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.

HuR, Molecular Glues

Chromatin/Epigenetic, PROTAC

3040248

C20H15N3O3

345.35

O=C1NC(=O)C(C2=COC=3C=C(C=CC32)C=4C=CN=C5NC=CC54)CC1

-20°C

Ice Packs

PROTAC