I-287 - CAS 2014368-93-3

I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].

Others, ERK, Protease-activated Receptor

MAPK, Others, GPCR/G Protein

2014272

C30H30ClFN4O4

565.04

C(C)(C)(C)C1=C2C(=NC(=C1)C3=CC(F)=C(Cl)C=C3)C=C(C(=O)N4C(C)(C)CN(CC4)C5=CC=C(C(O)=O)C=N5)O2

-20°C

Ice Packs

Small Compound