I-SAP - CAS 133538-58-6

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.

Others, Prostaglandin Receptor

Others, GPCR/G Protein, Immunology/Inflammation

133474

C22H30INO4S

531.45

C(/C=C\CCCC(O)=O)[C@H]1[C@]2(C(C)(C)[C@](C2)(C[C@@H]1NS(=O)(=O)C3=CC=C(I)C=C3)[H])[H]

-20°C

Ice Packs

Small Compound