I3IN-002 - CAS 552829-57-9

I3IN-002 is a small molecule inhibitor targeting the RNA-binding protein IGF2BP3, with an IC50 value of approximately 2 μM in SEM cells. It disrupts the interaction with m6A-modified mRNA, destabilizing target genes (such as CDK6, MYC, and BCL2), thereby inhibiting the growth of leukemia cells, inducing cell cycle arrest, and promoting apoptosis. I3IN-002 shows potential for research in B-cell acute lymphoblastic leukemia.

Apoptosis, IGF-1R

Tyrosine Kinase/Adaptors, Apoptosis

552763

C20H16F3N5OS

431.43

O=C(NC=1C=CC=CC1C(F)(F)F)CSC=2N=NC3=C(N2)NC4=CC=C(C=C34)CC

-20°C

Ice Packs

Small Compound