ICA-105665 - CAS 2694728-63-5

ICA-105665 (PF-04895162) is a potent and orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM) . ICA-105665 can penetrate the central nervous system (CNS) and has antiseizure effects [1][2][3][4].

Potassium Channel, Others

Membrane transporter/Ion channel, Others

2694660

C19H15F2N3O2

355.34

N(C(CC1=CC=C(F)C=C1)=O)N2C(=NC=3C(C2=O)=CC=C(F)C3)C4CC4

-20°C

Ice Packs

Small Compound