Icapamespib HCl - CAS 2267287-26-1

Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.

HSP, Others

Others, Cytoskeletal Signaling, Metabolism

2267260

C19H25Cl2IN6O2S

599.31

Cl.Cl.CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)ncnc12

-20°C

Ice Packs

Small Compound