Ici 216140 - CAS 124001-41-8

ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro) . At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rats.

Others, Bombesin Receptor

Others, GPCR/G Protein

123952

C45H65N13O8

916.08

C([C@H](NC([C@H](CC1=CN=CN1)NC(C(C)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(NC)=O)CC(C)C)=O)=O)C)=O)[C@H](C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4

-20°C

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