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Molfinity

IDH-305 - CAS 1628805-46-8

IDH-305 - CAS 1628805-46-8

MF-0015589-01

$48.87 USD
$48.87 USD
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Product Details

  • Bioactivity

    IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.

  • Target

    Isocitrate Dehydrogenase (IDH), Dehydrogenase

  • Related Pathways

    Metabolism

  • CAS Number

    1628751

  • Purity

    0.9968

  • Molecular Formula

    C23H22F4N6O2

  • Molecular Weight

    490.45

  • SMILES

    C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound