IDH2R140Q-IN-2 - CAS 2749568-16-7

IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML) .

Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Metabolism

2749545

0.9992

C21H18F6N6O

484.4

FC(F)(F)C=1C=CC=C(C1)NC=2N=C(N=C(N2)N3CCC(O)C3)NC4=CC=CC(=C4)C(F)(F)F

-20°C

Ice Packs

Small Compound