IDO1-IN-25 - CAS 2841467-86-3

IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS) . Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.

IDO, Indoleamine 2,3-Dioxygenase (IDO)

Metabolism

2841378

C14H8Cl3NO2S

360.64

O=S(C1=NC=2C=C(Cl)C(Cl)=CC2O1)CC3=CC=C(Cl)C=C3

-20°C

Ice Packs

Small Compound