IDO1/TDO-IN-9 - CAS 1878200-88-4

IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), with an IC50 value of less than 1 μM. It effectively inhibits the activity of IDO1 and TDO, preventing the degradation of tryptophan into kynurenine, thereby restoring immune activity in the tumor microenvironment and inhibiting tumor growth. IDO1/TDO-IN-9 shows potential for cancer research.

Indoleamine 2,3-Dioxygenase (IDO), IDO

Metabolism

1878108

C6H3ClFN3O

187.56

FC1=CC2=C(N=C1Cl)ON=C2N

-20°C

Ice Packs

Small Compound