IGF-1R modulator 1 - CAS 2375424-89-6

IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB) . This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.

EGFR, Trk receptor, IGF-1R

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2375424-89-6

C22H17N3O4

387.39

O=C1NC(=O)N(C2=CC=C(OC=3C=CC=CC3)C(=C2)C)C(=O)N1C=4C=CC=CC4

-20°C

Ice Packs

Small Compound