IHMT-TRK-284 - CAS 2416844-79-4

IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5 nM for TRKA, 0.7 nM for TRKB, and 2.6 nM for TRKC. The compound demonstrates good selectivity within the kinase group and exhibits significant anti-tumor efficacy in vivo.

PDGFR, c-Kit, Others, c-Fms, Apoptosis, Trk receptor, Bcr-Abl

Others, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis, Apoptosis

2416761

C25H27N7OS

473.59

C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(=CC3)C=4SC(NC(CN5CCN(C)CC5)=O)=NC4C)NN2

-20°C

Ice Packs

Small Compound