II399 - CAS 2928480-72-0

II399 is a potent and selective dual-substrate inhibitor of NNMT, featuring an unconventional SAM mimic, with a Ki value of 5.9 nM. It exhibits a notable competitive inhibition pattern against NAM and can occupy both the substrate and cofactor binding pockets. II399 shows promise for research in cancer, metabolic, cardiovascular, and neurodegenerative diseases.

Others

Others

2928408

C24H24ClN5O4

481.93

O[C@H]1[C@H](N2C=3C(C=C2)=C(Cl)N=CN3)C[C@H](CN(CC#CC4=CC(C(N)=O)=CC=C4)C(C)=O)[C@H]1O

-20°C

Ice Packs

Small Compound