IKD-8344 - CAS 129046-69-1

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species with diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties [1,2,3]. It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml) [1], inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml), and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia [2,3]. Additionally, it is active against T. spiralis in vitro and in vivo [1].

Antifungal, Others

Others, Microbiology/Virology

129046-69-1

C48H76O12

845.124

[H][C@@]12CC[C@]([H])(O1)[C@H](C)C(=O)O[C@]([H])(C[C@]1([H])CC[C@@]([H])(O1)[C@@H](C)C(=O)C[C@]1([H])CC[C@]([H])(O1)[C@H](C)C(=O)O[C@]([H])(C[C@]1([H])CC[C@@]([H])(O1)[C@@H](C)C(=O)C2)[C@@H](C)[C@]1([H])CC[C@@H](C)O1)[C@@H](C)[C@]1([H])CC[C@@H](C)O1

-20°C

Ice Packs

Small Compound